EMERGENCY CESAREAN SECTION FOR A RARE LIFE-THREATENING FETAL PATHOLOGY

  • Mihaela Amza Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania & The “Bucur” Maternity, “Saint John” Hospital, 040294 Bucharest, Romania
  • Fernanda-Ecaterina Augustin “Bucur” Maternity, “Saint John” Hospital, 040294 Bucharest, Romania
  • Tina-Ioana Bobei Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania & “Bucur” Maternity, “Saint John” Hospital, 040294 Bucharest, Romania
  • Cristina-Diana Popescu “Bucur” Maternity, “Saint John” Hospital, 040294 Bucharest, Romania
  • Romina-Marina Sima Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania & “Bucur” Maternity, “Saint John” Hospital, 040294 Bucharest, Romania
  • Liana Pleș Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania & “Bucur” Maternity, “Saint John” Hospital, 040294 Bucharest, Romania
  • Ileana-Maria Conea Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania & “Bucur” Maternity, “Saint John” Hospital, 040294 Bucharest, Romania
Keywords: cesarean section, alloimmunization, emergency

Abstract

Nowadays, fetal anemia is a rare cause of fetal hypoxia because the widely used ultrasound helps to identify it and makes antepartum management possible. We present a case of a 34-week pregnant woman with Rh incompatibility and alloimmunization associated with severe fetal anemia. In this case, urgent decision was needed to save the life of the fetus. A 24-year-old patient, G5 P2, 34 weeks pregnant, was presented to our emergency room for the lack of perception of active fetal movements for 24 hours. We mentioned that she was known to have Rh incompatibility and the last determination of anti Rh antibodies had a titer of 1:8 at 32 weeks of pregnancy. The ultrasound scan found modified values of the parameters on the middle cerebral artery indicating the presence of fetal anemia according to FMF (Fetal Medicine Foundation) algorithm for prediction anemia with an estimated fetal hemoglobin < 1.5 g/dl. Repeated CTGs indicated the presence of non-reassuring fetal status. An emergency cesarean delivery was decided to save the life of the fetus, which weighed 2600 g, had an Apgar index of 4 and a hemoglobin of 2.8 g/dl. The newborn showed signs of cardiomegaly, hepatomegaly, ascites and hydrops. The evolution of the newborn was favorable and he was discharged 14 days after birth. In conclusion, the ultrasound follow-up of patients with Rh incompatibility and alloimmunization is very important for the timely detection of possible changes in Doppler parameters. In a few cases, severe fetal anemia and non-reassuring fetal status occur, which indicates emergency cesarean section.

References

1. Todman D. A history of caesarean section: from ancient world to the modern era. Aust N Z J Obstet Gynaecol. 2007;47(5):357-361. doi:10.1111/j.1479-828X.2007.00757.x
2. Betran AP, Ye J, Moller AB, Souza JP, Zhang J. Trends and projections of caesarean section rates: global and regional estimates. BMJ Glob Health. 2021;6(6):e005671. doi:10.1136/bmjgh-2021-005671
3. Amyx M, Philibert M, Farr A, et al. Trends in caesarean section rates in Europe from 2015 to 2019 using Robson's Ten Group Classification System: A Euro-Peristat study. BJOG. Published online October 1, 2023. doi:10.1111/1471-0528.17670
4. Mylonas I, Friese K. Indications for and Risks of Elective Cesarean Section. Dtsch Arztebl Int. 2015;112(29-30):489-495. doi:10.3238/arztebl.2015.0489
5. ACOG Committee Opinion No. 761: Cesarean Delivery on Maternal Request. Obstet Gynecol. 2019;133(1):e73-e77. doi:10.1097/AOG.0000000000003006
6. Boyle A, Reddy UM, Landy HJ, Huang CC, Driggers RW, Laughon SK. Primary cesarean delivery in the United States. Obstet Gynecol. 2013;122(1):33-40. doi:10.1097/AOG.0b013e3182952242
7. Gravett C, Eckert LO, Gravett MG, et al. Non-reassuring fetal status: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine. 2016;34(49):6084-6092. doi:10.1016/j.vaccine.2016.03.043
8. German Society of Gynecology and Obstetrics (DGGG); Maternal Fetal Medicine Study Group (AGMFM); German Society of Prenatal Medicine and Obstetrics (DGPGM); German Society of Perinatal Medicine (DGPM). S1-Guideline on the Use of CTG During Pregnancy and Labor: Long version - AWMF Registry No. 015/036. Geburtshilfe Frauenheilkd. 2014;74(8):721-732. doi:10.1055/s-0034-1382874
9. Thompson L, Crimmins S, Telugu B, Turan S. Intrauterine hypoxia: clinical consequences and therapeutic perspectives. Research and Reports in Neonatology. 2015;5:79-89. https://doi.org/10.2147/RRN.S57990
10. Pereira S, Chandraharan E. Recognition of chronic hypoxia and pre-existing foetal injury on the cardiotocograph (CTG): Urgent need to think beyond the guidelines. Porto Biomed J. 2017;2(4):124-129. doi:10.1016/j.pbj.2017.01.004
11. Costumbrado J, Mansour T, Ghassemzadeh S. Rh Incompatibility. [Updated 2022 Dec 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459353/
12. Carles D, André G, Pelluard F, Martin O, Sauvestre F. Pathological Findings in Feto-maternal Hemorrhage. Pediatr Dev Pathol. 2014;17(2):102-106. doi:10.2350/13-12-1419-OA.1
13. Maier JT, Schalinski E, Schneider W, Gottschalk U, Hellmeyer L. Fetomaternal hemorrhage (FMH), an update: review of literature and an illustrative case. Arch Gynecol Obstet. 2015;292(3):595-602. doi:10.1007/s00404-015-3686-1
14. Wylie BJ, D'Alton ME. Fetomaternal hemorrhage. Obstet Gynecol. 2010;115(5):1039-1051. doi:10.1097/AOG.0b013e3181da7929
15. Stroustrup A, Plafkin C, Savitz DA. Impact of physician awareness on diagnosis of fetomaternal hemorrhage. Neonatology. 2014;105(4):250-255. doi:10.1159/000357797
16. Solomonia N, Playforth K, Reynolds EW. Fetal-maternal hemorrhage: a case and literature review. AJP Rep. 2012;2(1):7-14. doi:10.1055/s-0031-1296028
17. Basu S, Kaur R, Kaur G. Hemolytic disease of the fetus and newborn: Current trends and perspectives. Asian J Transfus Sci. 2011;5(1):3-7. doi:10.4103/0973-6247.75963
18. Akdağ A, Erdeve O, Uraş N, Simşek Y, Dilmen U. Hydrops Fetalis due to Kell Alloimmunization: A Perinatal Approach to a Rare Case. Turk J Haematol. 2012;29(1):72-75. doi:10.5505/tjh.2012.37801
19. Shourbagy S El, Elsakhawy M. Prediction of fetal anemia by middle cerebral artery Doppler. Middle East Fertility Society Journal. 2012;17(4):275-282. https://doi.org/10.1016/j.mefs.2012.09.003.
20. Prefumo F, Fichera A, Fratelli N, Sartori E. Fetal anemia: Diagnosis and management. Best Pract Res Clin Obstet Gynaecol. 2019;58:2-14. doi:10.1016/j.bpobgyn.2019.01.001
Published
2023-12-21